منابع مشابه
Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation
Human hepatocellular carcinomas (HCCs), which arise on a background of chronic liver damage and inflammation, express c-Fos, a component of the AP-1 transcription factor. Using mouse models, we show that hepatocyte-specific deletion of c-Fos protects against diethylnitrosamine (DEN)-induced HCCs, whereas liver-specific c-Fos expression leads to reversible premalignant hepatocyte transformation ...
متن کاملMICROBIAL TRANSFORMATION OF CHOLESTEROL BY MYCOBACTERIUM SMEGMATIS
Mycobacterium smegmatis PTCC 1307 (CIP 73.26) was used as a microbial agent to produce androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione, two useful precursors in the synthesis of steroid drugs. The side chain of cholesterol, as the substrate, was selectively cleaved in the presence of five enzyme inhibitors. An intermediate structure with intact side chain, cholest-4-ene-3-one, ...
متن کاملCarcinogenesis by radioactive substances.
Knowledge of the potential dangers of exposure to radioactive substances and the insti tution of proper safety precautions have helped to reduce accidental exposures to radioactive substances. However, the carcinogenic hazard from them has by no means been eliminated, and, in spite of the exercise of reasonable care and the use of improved technics, accidents in the laboratory and indust ry may...
متن کاملMICROBIAL CHAIN DEGRADATION OF CHOLESTEROL BY ARTHROB ACTER SIMPLEX
Because of the importance of microbial metabolites of cholesterol as precursors in the synthesis of steroidal drugs, we decided to study the ability of Arthrobacter simplex to degrade cholesterol. Arthrobacter simplex cleaves the side chain of cholesterol in the presence of 2,2'-dipyridyl and produces 4-androstene-3,17- dione (AD) and androsta- 1,4-diene-3,17-dione(ADD). Two other intermedi...
متن کاملReduction of serum cholesterol in hypercholesterolemic rats by Guar gum
Objective: Several diseases are reported to be uncommon in those parts of the world where dietary fiber intakes are high, therefore, in this study; we evaluated the hypocholesterolemiceffects of a dietary fiber (guar gum) in hypercholesteromic rats. Materials and Methods: Rats were fed high-fat or a normal fed diet for 12-week then treated with 5% guar gum in their regime during a 28 days peri...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1959
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1959.49